PDF Functions of Aurora kinase C in meiosis and cancer Biology Diagrams
PDF Functions of Aurora kinase C in meiosis and cancer Biology Diagrams Aurora A is localized to spindle poles where it provides spatial information for spindle functions in prometaphase. Aurora A is a kinase that is highly related to Aurora B but the two kinases localize to distinct subcellular regions during mitosis . From prometaphase to anaphase Aurora A localizes to the two poles of the spindle, which are the Abstract. Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function
For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their
Aurora kinases: structure, functions and their association ... Biology Diagrams
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors the G2/M transition by promoting centrosome maturation and mitotic spindle assembly. AurB and AurC are chromosome-passenger complex proteins, crucial for
During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore. They also regulate signalling by These inhibitors obstruct Aurora kinases, which in turn leads to aberrant mitosis. As a result, the p53-dependent checkpoint is activated and results in the induction of a G1-like cell-cycle arrest. Several small-molecule inhibitors of Aurora kinases, such as VX-680, PHA-739358 and AZD-1152, have shown anti-cancer effects in preclinical and Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution.
The cellular geography of Aurora kinases Biology Diagrams
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly
